I went back to the Apple TV series a little while ago to rewatch the clip where Harry talks about Nepal; in all honesty, it wasn't something I had picked up on much when the series first released. I don't know if this is the appropriate place to post this but since we're on the topic.
Oprah: Was there a moment, a single moment - or a series of experiences or encounters, happenings that forced you to say 'I need help?' Maybe 'I'm drinking too much, maybe I'm doing too much.' Was there an incident?
Harry: No, it was only when a couple of people close to me started to say, 'this isn't normal behavior. Perhaps you should seek help.' [...] Now in hindsight, looking back, it's all about timing. Towards my late twenties, everything became really hectic for me. But to the point of exhaustion. I was traveling all over the place because, you know, from a family's perspective I was the person who, like, "we need someone to go there. Uh, Nepal, Harry, you go." I was always the yes man, I was always the one who said yes. But that yes, yes, yes, yes, and yes led to burnout. It was like someone had taken a lid off all of the emotions I had suppressed for so many years, suddenly came to the forefront.
Viewed in the full context of Oprah's question and his full response, I have a hard time seeing how that can be interpreted as him disparaging Nepal or the value of the diplomatic tours he used to carry out. He's speaking in the context of a period of his life when his emotional state was worsening and that the pace of what he was being asked to do in terms of work (which of course is not anywhere near the average working person's) was one of the factors exacerbating that. He is not always articulate but I thought that was pretty clear. I don't think it's fair at all to say he hated the work he did.